Regulation of Bruton’s tyrosine kinase (Btk) by the peptidyl-rolyl isomerase Pin1
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چکیده
Regulation of Bruton’s tyrosine kinase (Btk) by the peptidyl-rolyl isomerase Pin1 Liang Yu, Abdalla J. Mohamed,* Leonardo Vargas, Anna Berglöf, Greg Finn, Kun Ping Lu, and C. I. Edvard Smith* Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, SE-4186, Stockholm, Sweden. Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA. Running Title: Pin1 regulates Btk *Address correspondence to: Abdalla J. Mohamed, and C. I. Edvard Smith, Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, SE-141 86, Stockholm, Sweden. Phone: +46-8-58583651; Fax: +46-8-58583650; Email: [email protected], [email protected]
منابع مشابه
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.
Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase (PPIase) Pin1 is a negative regulator of Btk, controlling its expression level by reducing its half-life, whereas...
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